Reduction of Seizure Occurrence from Exposure to Auditory Stimulation in Individuals with Neurological Handicaps: A Randomized Controlled Trial
نویسندگان
چکیده
BACKGROUND The purpose of this work was to determine in a clinical trial the efficacy of reducing or preventing seizures in patients with neurological handicaps through sustained cortical activation evoked by passive exposure to a specific auditory stimulus (particular music). The specific type of stimulation had been determined in previous studies to evoke anti-epileptiform/anti-seizure brain activity. METHODS The study was conducted at the Thad E. Saleeby Center in Harstville, South Carolina, which is a permanent residence for individuals with heterogeneous neurological impairments, many with epilepsy. We investigated the ability to reduce or prevent seizures in subjects through cortical stimulation from sustained passive nightly exposure to a specific auditory stimulus (music) in a three-year randomized controlled study. In year 1, baseline seizure rates were established. In year 2, subjects were randomly assigned to treatment and control groups. Treatment group subjects were exposed during sleeping hours to specific music at regular intervals. Control subjects received no music exposure and were maintained on regular anti-seizure medication. In year 3, music treatment was terminated and seizure rates followed. We found a significant treatment effect (p = 0.024) during the treatment phase persisting through the follow-up phase (p = 0.002). Subjects exposed to treatment exhibited a significant 24% decrease in seizures during the treatment phase, and a 33% decrease persisting through the follow-up phase. Twenty-four percent of treatment subjects exhibited a complete absence of seizures during treatment. CONCLUSION/SIGNIFICANCE Exposure to specific auditory stimuli (i.e. music) can significantly reduce seizures in subjects with a range of epilepsy and seizure types, in some cases achieving a complete cessation of seizures. These results are consistent with previous work showing reductions in epileptiform activity from particular music exposure and offers potential for achieving a non-invasive, non-pharmacologic treatment of epilepsy. TRIAL REGISTRATION Clinicaltrials.gov NCT01459692.
منابع مشابه
Effect of Transcranial Direct Current Stimulation on Auditory-Verbal Memory in Healthy Elderly
Background and purpose: Auditory-verbal memory decreases with age. One method to compensate this weakness is transcranial direct current stimulation. The current study investigated the effect of Anodal Transcranial Direct Current Stimulation on auditory-verbal memory performance of healthy elderly people. Materials and methods: In a randomized clinical trial, 42 healthy subjects with no histor...
متن کاملGroup Emotion Regulation Therapy for Illness Anxiety Disorder: A Randomized Controlled Trial
Background & Objective: People with Illness Anxiety Disorder experience excessive worry and in this regard, they have a lot in common with Generalized Anxiety Disorder. Emotion Regulation Therapy (ERT) is a multifaceted and integrated treatment that is widely used for Generalized Anxiety Disorder and its effectiveness in anxious factors has been established in many studies. The aim of the pres...
متن کاملSaffron supplements modulate serum pro-oxidant-antioxidant balance in patients with metabolic syndrome: A randomized, placebo-controlled clinical trial
Objectives: We have investigated the effect of a saffron supplement, given at a dose of 100 mg/kg, on prooxidant-antioxidant balance (PAB) in individuals with metabolic syndrome. Materials and Methods: A randomized, placebo-controlled trial design was used in 75 subjects with metabolic syndrome who were randomly allocated to one of two study groups: (1) the case group received 100mg/kg saffron ...
متن کاملFlexible Multi-dose GnRH Antagonist versus Long GnRH Agonist Protocol in Poor Responders: A Randomized Controlled Trial
Background To compare a flexible, multi-dose GnRH antagonist protocol with a long GnRH .agonist protocol in poor respo MaterialsAndMethods A randomized clinical trial of 70 poor responder patients (35 patients in GnRH antagonist protocol and 35 patients in long GnRH agonist protocol) was performed at Royan Institute, Tehran, Iran. Both groups were given a fixed dose of human menopausal gonadotr...
متن کاملتشخیص و بررسی کاهش دامنۀ P300 در پتانسیلهای وابسته به رویداد شنوایی تکثبت با استفاده از الگوریتم ژنتیک و طبقه بندیکنندۀ شبکۀ عصبی
Abstract P300 is known as the most prominent component between cognitive components in electrical brain activity. According to done research, when brain encounters an inconsistent stimulation during processing a series of usual stimulation, a P300 component appears in recorded brain signal which could distinguishes from usual ones. Amplitude of P300 decreases after a short during act of auditor...
متن کامل